ANTITUBERCULOUS IMMUNITY IN MICE VACCINATED WITH KILLED TUBERCLE BACILLI
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چکیده
منابع مشابه
Antituberculous Immunity in Mice Vaccinated with Killed Tubercle Bacilli
The resistance of white mice to tuberculous infection could be increased by preliminary vaccination with small amounts of tubercle bacilli killed by contact with 2 per cent phenol. Vaccine prepared from a variant strain of human tubercle bacilli unable to multiply in vivo (H37Ra) proved as active as vaccines prepared from either virulent or attenuated strains. The immunity induced by phenol-kil...
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It proved possible to increase the resistance of mice to tuberculous infection by vaccinating them with a suspension of avirulent tubercle bacilli killed by exposure to 2 per cent phenol. This increase in resistance was demonstrated by two different techniques: (a) observation of survival time of vaccinated animals following challenge infection with a large dose of virulent bacilli, and (b) det...
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The immunity induced in mice by vaccination with living attenuated cultures of tubercle bacilli was measured by two criteria. (a) Increase in survival time of the vaccinated animals after infection with a dose of virulent bacilli sufficient to kill all the unvaccinated controls within 10 to 20 days. (b) Difference in the number of living bacilli recovered from the spleen and lungs of vaccinated...
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It is possible to prepare from tubercle bacilli a fraction soluble in methanol which is capable of eliciting in mice a marked degree of resistance against virulent tuberculous infection. The immunity was evident whether the infective dose was large and caused a disease with a rapid course, or was very small and caused a disease of many months duration. Active material has been obtained by extra...
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1. Rabbits vaccinated with tubercle bacilli killed by exposure to formalin (0.4 per cent) did not show any acquired resistance to subsequent infection with bovine tubercle bacilli, while rabbits vaccinated with tubercle bacilli which had been killed by heating to 70 degrees for 1 hour survived more than half as long again as their controls. 2. Intraperitoneal injection of either the formalin-ki...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1953
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.97.2.221